The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
Meihan Liu, Edmund R. R. Moody, Farrah Blades, Caroline Puente-Lelièvre, Kai‐En Chen, Ella J. Stephens, Katharine A. Michie, Rosemary J. Cater, Tom A. Williams, Brett M. Collins, Michael D. Healy
This study identifies bacterial and archaeal ancestors of eukaryotic COMMD proteins through structural and phylogenetic analysis, showing their origin from a single bacterial gene.
Nature Communications · May 29, 2026Peer-reviewedBiochemistry