A Paracrine Dietary Lipid Axis Constrains Antitumor Immunity in Liver Cancer
Nicolae Ciobu, Reena Kumari, Jeevotham S. Kumar, Ugne Balaseviciute, Maria Iftesum, Jonathan Mitchell, Justin Ruiz, Sara Flowers, Kaila Nishikawa, Guillem Cano-Segarra, Anna Vila-Escoda, Yang Xiao, Aiden M. Phoebe, Raúl Navaridas, Marcella Steffani, , Viraj R. Sanghvi
This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.
bioRxiv · Jun 26, 2026 · PreprintCancer Biology