Yang Xiao

This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.

The paper identifies compact CRISPR-based activators with durable gene activation, improving upon existing tools in potency and persistence.

The paper presents 545 silkworm genomes to explore genotype-phenotype relationships, identifying new genes and variants linked to domestication and adaptation.