This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

bioRxiv · Jun 26, 2026 · PreprintCancer Biology

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

Asmita Pathak, Sravya Palavalasa, Bruno Colon, Erika Ciervo, Yadi Zhou, Oriana Teran Pumar, Brandon Emanuel León, Jonathan Mitchell, Pedro Henrique Assenza Tavares Coroa, Beatriz Mateo-Victoriano, Andrew J. Scott, Durga Prasad Gannamedi, Harrison K. A. Wong, Liping Zhang, Juyeun Lee, , Defne Bayık

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Nature Cancer · Jun 23, 2026Peer-reviewedCancer Biology

NAB2-STAT6 Fusion Proteins Drive Nuclear Condensate Formation and Transcriptional Reprogramming in Solitary Fibrous Tumors

Yi Li, Jose Lucinio Mondaza-Hernandez, Gauthami Pulivendala, Fardous F. El‐Senduny, Felipe Beckedorff, Guilherme Miura Lavezzo, Farhan Vahdat Azad, Zikun Zhou, Jeremy Warren, Paulina I. Trevino, Clark A. Meyer, David B. Lombard, Javier Martín‐Broto, David S. Moura, Heather N. Hayenga, Leonidas G. Bleris

This study shows NAB2-STAT6 fusion proteins form nuclear condensates that drive transcriptional changes in SFT, and Mithramycin A disrupts these condensates.

Cancer Letters · May 22, 2026Peer-reviewedCancer Biology

Pharmacologic DPP-4 inhibition promotes CD8⁺ T cell metabolic fitness to enhance anti-tumor activity

Oriana Teran Pumar, Elton L VanNoy, Abigail Haffey, Durga Prasad Gannamedi, Christine Isabelle Rafie, Dylan Scott Lykke Harwood, Julia R. Benedetti, Christine Ann Pittman Ballard, Erika Ciervo, Pedro Henrique Assenza Tavares Coroa, Payal Grover, Brandon Emanuel León, Jonathan Mitchell, Asmita Pathak, Bruno Colon, , Defne Bayık

This study shows that DPP-4 inhibition improves CD8+ T cell metabolism and anti-tumor activity in preclinical and clinical settings.

bioRxiv · Apr 3, 2026 · PreprintImmunology

Targeting Endoplasmic Reticulum Stress and Nitroso-Redox Imbalance in Neuroendocrine Prostate Cancer: The Therapeutic Role of Nitric Oxide

Fakiha Firdaus, Osmel Companioni, Raúl A Dulce, Anusha Edupuganti, Surinder Kumar, Khushi Hemendra Shah, Salih Salihoglu, Derek J. Van Booven, Richard Gasca, David B. Lombard, Joshua M. Hare, Fangliang Zhang, Rehana Qureshi, Himanshu Arora

This study identifies ER stress and nitroso-redox imbalance as key drivers of NEPC progression and shows that NO supplementation reduces tumor burden and metastasis in mice.

Cell Death Discovery · Nov 6, 2025Peer-reviewedCancer Biology

SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology

Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya M. Al-Murshedi, , David B. Lombard

The paper identifies two SIRT5 variants in mitochondrial disease patients that reduce protein stability and activity but not neuropathology, using biochemical and mouse model analyses.

bioRxiv · Dec 6, 2023 · PreprintGenetics

Integration of high-content fluorescence imaging into the metabolic flux assay reveals insights into mitochondrial properties and functions

Andrew C. Little, Ilya Kovalenko, Laura Goo, Hanna S. Hong, Samuel A. Kerk, Joel A. Yates, Vinee Purohit, David B. Lombard, Sofia Diana Merajver, Costas Andreas Lyssiotis

The paper integrates high-content fluorescence imaging with metabolic flux assays to improve normalization and analyze mitochondrial properties in cancer cells.

Communications Biology · May 29, 2020Peer-reviewedMolecular Biology