Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans
Amanda O. Shaver, Isabella R. Miller, Etta S. Schaye, Nicolas D. Moya, J.B. Collins, Janneke Wit, Alyssa H. Blanco, Fiona M. Shao, Elliot J. Andersen, Sharik A. Khan, Gracie Paredes, Erik C. Andersen
This study quantifies the fitness effects of resistance alleles to albendazole and ivermectin in C. elegans, finding that resistance requires specific gene deletions and that multi-drug resistance is not observed.
PLoS Pathogens · May 20, 2024Peer-reviewedGenetics