Janneke Wit

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants

The paper identifies 94 candidate genes in C. elegans linked to susceptibility to 23 environmental toxicants using genome-wide association analysis.

Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans

This study quantifies the fitness effects of resistance alleles to albendazole and ivermectin in C. elegans, finding that resistance requires specific gene deletions and that multi-drug resistance is not observed.

Praziquantel inhibits Caenorhabditis elegans development and species-wide differences might be cct-8-dependent

This study investigates praziquantel's effects on C. elegans development and identifies potential genetic factors, including cct-8, that influence susceptibility.

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans strains

This study identifies genetic differences among C. elegans strains that drive variation in anthelmintic responses across multiple drug classes, highlighting the importance of genetic diversity in understanding anthelmintic resistance.

Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchus contortus field populations

This study identifies genomic signatures of benzimidazole drug resistance in Haemonchus contortus using field populations with defined treatment histories, showing the isotype-1 β-tubulin gene as the primary resistance locus.

Two novel loci underlie natural differences in Caenorhabditis elegans macrocyclic lactone responses

The paper identifies three genomic regions in C. elegans associated with natural variation in macrocyclic lactone response, including two novel loci and one previously known locus.

Extensive genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

The paper presents a high-quality, chromosome-scale genome assembly of Haemonchus contortus using long-read sequencing, revealing genetic diversity and transcriptional regulation.

A database for ITS2 sequences from nematodes

The paper presents a database of ITS2 sequences from nematodes and the software used to build it, along with tools to create ITS2 databases for other taxonomies.

Nanopore sequencing of Giardia reveals widespread intra-isolate structural variation

The paper uses Nanopore sequencing to generate high-quality genomes and identify structural variants in Giardia isolates, revealing heterozygosity and variant-specific surface proteins.