HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs
Derk Draper, Anna E. George, Tineke Veenendaal, Suzanne van Dijk, Elly Soltani, Paolo Sanzà, Frederik J. Verweij, Judith Klumperman, Ginny G. Farı́as
This study shows that HOPS disruption impairs APP trafficking, leading to accumulation of APP-CTFs in endosomes and their exosomal secretion, which may contribute to Alzheimer's disease progression.
Neurobiology of Disease · Jan 10, 2026Peer-reviewedCell Biology