Ginny G. Farı́as

This study shows TMEM55B and TMEM55A regulate lysosome distribution in neurons by affecting motor protein transport, with TMEM55B specifically promoting anterograde transport of LAMP1-positive organelles.

The paper uses spatiotemporal proteomics to study the trafficking and localization of NLGN1 and NLGN2 to the axon initial segment, revealing distinct sorting mechanisms and functional roles.

This study investigates the roles of CSTN1 and CSTN3 in axonal cargo transport, finding they coordinate TGN exit and regulate RAB6A levels to influence Golgi organization and trafficking.

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

This study shows that HOPS disruption impairs APP trafficking, leading to accumulation of APP-CTFs in endosomes and their exosomal secretion, which may contribute to Alzheimer's disease progression.

The paper identifies a mechanism where axonal ER couples translation and secretion of transmembrane proteins to support axonal development.

The paper develops POTATOMap to study biosynthetic lysosomal protein trafficking in neurons, revealing domain-specific mechanisms and interactions.

This study identifies axonal ER tubules and P180/RRBP1 as regulators of local mRNA translation in axons, showing their role in ribosome interactions and proteome dynamics.