HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs
Derk Draper, Anna E. George, Tineke Veenendaal…·Ginny G. Farı́as
This study shows that HOPS disruption impairs APP trafficking, leading to accumulation of APP-CTFs in endosomes and their exosomal secretion, which may contribute to Alzheimer's disease progression.