Frederik J. Verweij

The paper benchmarks biotin enrichment in proximity labeling proteomics, showing that higher biotinylation improves specificity while lower levels increase background noise.

This study identifies TSPAN3 as a marker of a distinct secretory multivesicular body population with unique trafficking and EV composition compared to CD63-positive compartments.

The paper identifies MARCKSL1 as a regulator of extracellular vesicle secretion pathways through a CRISPR activation screen and functional studies.

This study shows that HOPS disruption impairs APP trafficking, leading to accumulation of APP-CTFs in endosomes and their exosomal secretion, which may contribute to Alzheimer's disease progression.

This study uses expansion microscopy to show SARS-CoV-2 exits cells via Rab27-dependent amphisome fusion, identifying a potential therapeutic target.

This study investigates how hypoxia and TNF-alpha affect extracellular vesicle release from hiPSC-CMs under stress conditions, identifying nSmase2 and mTOR signaling pathways involved.

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

ExoJ is an ImageJ2/Fiji plugin that automates the detection and analysis of exocytosis events, providing quantitative features and robust performance across varying signal-to-noise ratios.