Ex vivo Model of Functioning Human Lymph Node Reveals Pivotal Role for Innate Lymphoid Cells and Stromal Populations in Response to Vaccine Adjuvant
Joannah R. Fergusson, Jacqueline H. Y. Siu, Nitya Gupta, Edward M. Jenkins, Eloise Nee, Sören Reinke, Tamara Ströbel, Ananya Bhalla, Shyami Menaka Kandage, Thomas Courant, Sarah Hill, Moustafa Attar, Michael Loran Dustin, Alex Nicolas Gordon-Weeks, Mark Christopher Coles, , Anita Milicic
This study uses ex vivo human lymph node slices to investigate immune responses to a vaccine adjuvant, identifying IL-1β secretion as TLR4-dependent and highlighting roles for innate lymphoid and stromal cells.
Cell Reports · Jul 1, 2025Peer-reviewedImmunology