Edward M. Jenkins

This paper develops artificial and semi-artificial 3D membrane systems to study protein, lipid, and glycocalyx distribution at cell-cell interfaces, revealing differential partitioning and activation dynamics.

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

The paper introduces u-Segment3D, a tool that converts 2D cell segmentations into 3D consensus segmentations without training data, demonstrating effectiveness across diverse datasets.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

This study uses ex vivo human lymph node slices to investigate immune responses to a vaccine adjuvant, identifying IL-1β secretion as TLR4-dependent and highlighting roles for innate lymphoid and stromal cells.

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

The paper uses bulk RNA-seq and single-cell RNA-seq data to study T-cell expansion and identifies FOSL1 as a transcription factor that promotes an effector phenotype, enhancing cancer-cell killing.

The paper introduces u-Unwrap3D to map 3D cell surfaces and analyze interactions between geometry and molecular signals, revealing new dynamics in immune and tumor cell behaviors.