Michael Loran Dustin

The paper shows that TCR and IL2 receptor signaling synergize at the immunological synapse of CD8+ T cells, enhancing T-T synapse formation and function.

This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.

This study shows interferon-γ increases thrombospondin-4 expression in CTLs, promoting SMAP production and enhancing anti-tumor killing.

This study shows PTPN22 regulates actin remodeling via PSTPIP-1 during T cell synapse formation, affecting TCR clustering and activation.

This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.

This study identifies that organized tertiary lymphoid structures (TLSs) with coordinated B and T cell zoning are associated with durable survival in pancreatic cancer, contrasting with disorganized TLSs in short-term survivors.

This study shows that Kv1.3 palmitoylation regulates its spatial distribution and removal from the immunological synapse, impacting T cell activation and autoimmune disease.

The paper shows RIFINs of Plasmodium falciparum bind LILRB1 in different conformations, triggering inhibitory signaling either in trans or cis to suppress immune responses.

This study shows PD-1 blockade enhances T cell activation by altering ligand interactions between CD28, CTLA4, and PD-1, leading to stronger CD28-CD80 co-stimulation.

The paper introduces QuEST immunofluorescence microscopy to quantify TCR signalosome stoichiometries in human T cells, revealing a 1:1 ZAP-70:TCR ratio and CD28 recruitment independent of CD80/CD86.

This paper develops artificial and semi-artificial 3D membrane systems to study protein, lipid, and glycocalyx distribution at cell-cell interfaces, revealing differential partitioning and activation dynamics.

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

The paper develops hybrid 3D cancer cultures using synthetic and natural cells to mimic tumor immune microenvironments and identify immune evasion mechanisms.

The paper shows CD4 T cells release telomere-rich vesicles called Rivers, which rejuvenate senescent tissues and extend lifespan in mice.

This paper develops a method to isolate and characterize SMAPs from NK-92 cells, showing their cytotoxic activity against tumor cells in vitro and in vivo.

The paper describes stenocytosis, a mechanism by which CTLs transfer supramolecular attack particles into target cells through narrow actin gaps.

The paper identifies ThrEDs, a novel type of extracellular particle that accelerates wound healing and reduces fibrotic responses in patient-derived myofibroblasts.

This study uses ex vivo human lymph node slices to investigate immune responses to a vaccine adjuvant, identifying IL-1β secretion as TLR4-dependent and highlighting roles for innate lymphoid and stromal cells.

SpatioEv analyzes spatial data to reveal cell and neighborhood dynamics, identifying disease-specific spatial signatures and developmental trajectories in tissues.

The paper identifies RIFINs that bind both inhibitory and activating KIR receptors, revealing their role in modulating NK cell activation during malaria infection.

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

This study identifies a JAK-independent mechanism of STAT3 activation in RA through TCR-dependent phosphorylation at the immunological synapse, suggesting a new therapeutic target.

This study characterizes extracellular vesicles from activated CD4 T cells and shows their pro-inflammatory effects on antigen-presenting cells, providing a resource for EV-based therapeutic development.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

This study compares cytokine production kinetics in TCR-T cells and CAR-T cells with and without co-stimulation, finding that 2nd-generation CAR-T cells sustain cytokine production without co-stimulation.

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

This study examines how different costimulatory receptors affect T cell activation and identifies genetic risk factors for inflammatory diseases through RNA-seq and ATAC-seq in human CD4+ T cells.