Mark Christopher Coles

Gut archaea drive human MAIT cell responses

The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.

Tissue resident memory T cells populate the human uveal tract

The paper identifies resident memory T cells in the human uveal tract, showing their presence in both healthy and inflamed states and their potential role in uveitis.

Lipopolysaccharide lateral mobility in the Gram-negative bacterial outer membrane is confined and governed by interactions within the conserved Lipid A anchor

This study shows lipopolysaccharide in Gram-negative bacteria is laterally confined in the outer membrane due to magnesium and hydrophobic interactions, a feature conserved across species.

Machine perfusion and single-cell spatial transcriptome mapping identifies novel immune escape mechanisms in colorectal cancer liver metastasis

Early regional lymph node activation drives influenza vaccine responses in an ancestrally diverse cohort

This study examines immune responses in ancestrally diverse individuals after influenza vaccination, finding that draining lymph nodes show rapid activation and specific cellular changes.

The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

Ex vivo Model of Functioning Human Lymph Node Reveals Pivotal Role for Innate Lymphoid Cells and Stromal Populations in Response to Vaccine Adjuvant

This study uses ex vivo human lymph node slices to investigate immune responses to a vaccine adjuvant, identifying IL-1β secretion as TLR4-dependent and highlighting roles for innate lymphoid and stromal cells.

An end-to-end framework for Cell DIVE multiplexed imaging and spatial immune microenvironment analysis

RNA editing is a molecular clock in unmodified human cells

This paper introduces T2, a method using RNA editing to estimate transcriptional age and identify transient transcriptional programs in human cells.

Spatial programming of fibroblasts promotes resolution of tissue inflammation through immune cell exclusion

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases