Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease
Jennifer Hua, Elvira Garcia De Paco, Nathalie Linck, Tangui Maurice, Catherine M. Desrumaux, Bénédicte Manoury, François Rassendren, Lauriane Ulmann
This study shows that microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer's disease by enhancing lysosomal activity and reducing Aβ clearance.
bioRxiv · May 12, 2022 · PreprintNeuroscience