This study shows that chronic FENM infusion protects against Aβ25-35-induced neurotoxicity and improves memory in AD mouse models, with better efficacy than MEM.

Alzheimer s Research & Therapy · Jan 6, 2025Peer-reviewedPharmacology & Toxicology

The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice.

Simone Patergnani, Méghane S. Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, René Valéro, Lisbeth Tranebjærg, Tangui Maurice, Paolo Pinton, Benjamin Delprat, Élodie M. Richard

This study shows that the WFS1E864K variant reduces MAM integrity and disrupts autophagy and mitophagy in human and mouse models of Wolfram-like syndrome.

bioRxiv · Nov 16, 2023 · PreprintNeuroscience

Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease

Jennifer Hua, Elvira Garcia De Paco, Nathalie Linck, Tangui Maurice, Catherine M. Desrumaux, Bénédicte Manoury, François Rassendren, Lauriane Ulmann

This study shows that microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer's disease by enhancing lysosomal activity and reducing Aβ clearance.

bioRxiv · May 12, 2022 · PreprintNeuroscience

Restoring Glutamate receptosome dynamics at synapses rescues Autism-like deficits in Shank3-deficient mice.

Enora Moutin, Sophie Sakkaki, Vincent Compan, Nathalie Bouquier, Federica Giona, Julie Areias, Elise Goyet, Anne-Laure Hemonnot-Girard, Vincent Seube, Bastien Glasson, Nathan Bénac, Yan Chastagnier, Fabrice Raynaud, Étienne Audinat, Laurent Groc, , Julie Perroy

This study shows that restoring glutamate receptosome dynamics in Shank3-deficient mice rescues synaptic and behavioral deficits associated with autism.

Molecular Psychiatry · Jul 30, 2021Peer-reviewedNeuroscience