Nathalie Linck

ZFP36 is a post-transcriptional regulator of the P2X4 receptor in myeloid cells

The paper identifies ZFP36 as a post-transcriptional regulator of P2X4 receptor expression in myeloid cells, revealing a novel mechanism linking myeloid cell state to purinergic responsiveness.

APPNL-F knock-in Alzheimer's Disease model mice reveal etiological convergence of aging and amyloidosis

This study characterizes the early stages of amyloidosis and neuroinflammation in APPNL-F AD model mice, revealing a link between microglial senescence and disease progression.

Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease

This study shows that microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer's disease by enhancing lysosomal activity and reducing Aβ clearance.

P2X-GCaMPs as versatile tools for imaging extracellular ATP signaling

The paper develops P2X-GCaMP biosensors to detect extracellular ATP with high sensitivity and tracks ATP release in response to neuronal depolarization and hypotonicity.