Author

Elzbieta Kierzek

Institute of Bioorganic Chemistry, Polish Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David H. MathewsiD· 4 shared Ryszard KierzekiD· 4 shared Megan MiaroiD· 3 shared Olivia M. Hiltke· 3 shared Thandolwethu S. Shabangu· 3 shared Brent M. ZnoskoiD· 2 shared Elizabeth A. JolleyiD· 2 shared Marta Soszynska-Jozwiak· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

David H. MathewsORCID

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Author profile →

4 papers

Recent·Most cited

Longer Is Not Always Better: Effects of Equilibration Length on Umbrella Sampling Estimations for RNA Hairpin Folding Stabilities

Olayinka Akinyemi, Elzbieta Kierzek, Ryszard Kierzek, James P McSally, Anees Mohammed Keedakkatt Puthenpeedikakkal, David H. Mathews

This study shows that longer equilibration times in umbrella sampling can alter free energy landscapes and reduce agreement with experimental data for RNA hairpin folding.

bioRxiv · Sep 16, 2026 · PreprintBiophysics

Nearest Neighbor Parameters for Estimating RNA Folding Stability with In Vivo-like Conditions

Olivia M. Hiltke, Elzbieta Kierzek, Martina Prochota, Marta Rachwalak, Megan Miaro, Thandolwethu S. Shabangu, Sylwia Górczyńska, Ryszard Kierzek, David H. Mathews

The paper develops a new RNA folding model using in vivo-like ionic conditions, improving tRNA structure prediction but showing minimal overall impact on secondary structure predictions.

bioRxiv · Sep 8, 2026 · PreprintBiochemistry

Nearest Neighbor Parameters for Estimating the Folding Stability of RNA Including Pseudouridine

Thandolwethu S. Shabangu, Elzbieta Kierzek, Sebastian J. Arteaga, Gregory S. Orf, Julia Stone, Olivia M. Hiltke, Megan Miaro, Elizabeth A. Jolley, Marta Soszynska-Jozwiak, Marta Szabat, Sharon Aviran, Philip C. Bevilacqua, Brent M. Znosko, Ryszard Kierzek, David H. Mathews

This paper presents nearest neighbor parameters for estimating RNA folding stability with pseudouridine, derived from optical melting experiments, and demonstrates their application in modeling RNA secondary structures.

bioRxiv · May 17, 2026 · PreprintBiochemistry

RNA Folding Nearest Neighbor Parameters Including the Modification 1-Methyl-Pseudouridine

Elzbieta Kierzek, Thandolwethu S. Shabangu, Olivia M. Hiltke, Megan Miaro, Sebastian J. Arteaga, Brent M. Znosko, Elizabeth A. Jolley, Philip C. Bevilacqua, John SantaLucia, Holly A. SantaLucia, Hainin Lin, Mihir Metkar, Sharon Aviran, Marta Soszynska-Jozwiak, Ryszard Kierzek, David H. Mathews

This paper develops new RNA folding nearest neighbor parameters for sequences containing 1-methyl-pseudouridine, showing it stabilizes RNA folding and improves tRNA ensemble modeling.

bioRxiv · Apr 11, 2026 · PreprintBioinformatics