Philip C. Bevilacqua

This study shows that coacervates protect RNA from hydrolysis during wet-dry cycling with Mg2+ by creating a stable microenvironment, as demonstrated with an unstructured RNA and a ligase ribozyme.

The paper optimizes tRNA Structure-seq to improve tRNA secondary structure prediction accuracy in S. cerevisiae and shows tRNA structures remain stable under mild stress.

This paper presents nearest neighbor parameters for estimating RNA folding stability with pseudouridine, derived from optical melting experiments, and demonstrates their application in modeling RNA secondary structures.

This paper develops new RNA folding nearest neighbor parameters for sequences containing 1-methyl-pseudouridine, showing it stabilizes RNA folding and improves tRNA ensemble modeling.

The paper identifies the prevalence and structural contexts of dual-donating amines in structured RNAs using computational analysis of RNA structures.

This study investigates how coacervates resist changes in molecular composition under varying salinity and pH, showing they can buffer molecules like RNA and maintain internal stability.

The paper identifies and characterizes shifted GU wobble pairs in RNA through cheminformatics and experimental validation, showing alternative protonation states may enhance RNA function.

The paper tests over 2,600 natural twister ribozymes using CHiTA, finding 94% are active and showing structural tolerance.

The paper introduces the FRID pipeline to identify potential pseudoknot-containing RNA elements in SARS-CoV-2 as therapeutic targets, finding 22 functional RNA elements with 14 having conserved pseudoknots.