Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study
Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel Nabulsi, Yiyun Henry Huang, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca
This study uses PET imaging to show a strong positive correlation between mGluR5 and synaptic density in early AD patients and cognitively normal individuals, suggesting mGluR5 may mediate early synaptic loss in AD.
Alzheimer s Research & Therapy · May 6, 2025Peer-reviewedPathology