Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation
Jiayi Pei, Renée G. C. Maas, Ema Nagyova, Johannes M.I.H. Gho, C. Snijders Blok, Iris van Adrichem, Jorg J. A. Calis, René van Es, Shahrzad Sepehrkhouy, Dries A. M. Feyen, Noortje A. M. van den Dungen, Nico R. Lansu, Nicolaas de Jonge, Hester M. den Ruijter, Manon M. H. Huibers, , Magdaléna Harakaľová
The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.
bioRxiv · Nov 30, 2020 · PreprintGenomics