Boudewijn M.T. Burgering

Single Cell Proteomics reveals partial uncoupling of the Glycerol-3-Phosphate shuttle to compensate for Electron Transport Chain dysfunction in Alexander Disease GFAP mutations

The paper uses single-cell proteomics to show that GFAP mutations in Alexander disease lead to ETC dysfunction and metabolic adaptation via the G3P shuttle.

Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent manner.

This study shows that localized hydrogen peroxide production induces p53-dependent resistance to DNA damage, with implications for chemotherapy protection.

Organoid-evaluable clinical biomarkers predict drug responses and guide new breast cancer therapies

The paper develops predictive models using patient-derived breast cancer organoids to identify drug responses and guide new therapies for resistant disease.

Direct detection of 8-oxo-dG using nanopore sequencing

The paper develops a method to directly detect 8-oxo-dG using nanopore sequencing by creating synthetic DNA with context variability and training deep learning models.

Global analysis of protein arginine methylation

The paper develops an NMR-based method to quantify global protein arginine methylation levels across various biological samples and demonstrates its prevalence and modulation in health and disease.

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

The paper identifies a FOXO-dependent mechanism that restricts proliferation of cells with mild replication stress by promoting premature activation of APC/CCDH1.

Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation

The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.

MetaboShiny - interactive processing, analysis and annotation of direct infusion metabolomics data

MetaboShiny provides an interactive tool for analyzing and annotating direct infusion metabolomics data, demonstrating its use on lung cancer urine samples.