Hester M. den Ruijter

Sex-Specific Regulation of Endothelial-to-Mesenchymal Transition (EndMT) During Atherosclerosis

The paper examines sex-specific regulation of EndMT in atherosclerosis using bulk RNA-seq and single-cell transcriptomics, identifying key regulators and stage-dependent differences.

Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques

This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.

Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease

The paper integrates multi-modal omics data to identify therapeutic pathways in atherosclerosis for coronary heart disease, highlighting amino acid metabolism and 16 relevant proteins.

Identification of endothelial-to-mesenchymal transition gene signatures in single-cell transcriptomics of human atherosclerotic tissue

The paper identifies gene signatures of endothelial-to-mesenchymal transition in human atherosclerotic tissue using combined in vitro and single-cell transcriptomic data.

Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

The paper identifies female-biased VSMC gene regulatory networks and highlights MYH9 as a key regulator of fibrous plaque phenotype in females.

Comprehensive identification of coronary artery disease-associated variants regulating vascular smooth muscle cell gene expression

This study identifies CAD-associated variants regulating vascular smooth muscle cell gene expression through functional assays and eQTL integration.

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genes

The paper identifies eQTLs and sQTLs in human aortic SMCs that colocalize with CAD GWAS loci, highlighting splicing regulation as a mechanism for CAD risk.

Sex dependent gene activity in the human body

The paper maps sex-dependent gene activity across 24 human tissues using RNA-sequencing data and identifies sex-biased genes and pathways.

Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women.

Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation

The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.

Family history and polygenic risk of cardiovascular disease: independent factors associated with secondary cardiovascular manifestations in patients undergoing carotid endarterectomy

This study examines the association between family history and polygenic risk scores with secondary cardiovascular events in patients undergoing carotid endarterectomy, finding both factors independently increase risk.