Enhanced axonal Neuregulin-1 type-III signaling ameliorates disease severity in a CMT1B mouse model
Cristina Scapin, Cinzia Ferri, Emanuela Pettinato, Desirée Zambroni, Francesca Bianchi, Ubaldo Del Carro, Sophie Belin, Donatella Caruso, Nico Mitro, Marta Pellegatta, Carla Taveggia, Markus H. Schwab, Klaus‐Armin Nave, M. Laura Feltri, Lawrence G. Wrabetz, Maurizio D’Antonio
This study shows that enhancing Nrg1TIII signaling reduces disease severity in a CMT1B mouse model by rebalancing myelin lipids and proteins, not through myelin gene upregulation.
bioRxiv · Aug 7, 2018 · PreprintNeuroscience