Markus H. Schwab

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.

This study shows that enhancing Nrg1TIII signaling reduces disease severity in a CMT1B mouse model by rebalancing myelin lipids and proteins, not through myelin gene upregulation.