Cristina Scapin

Treatment with IFB-088 improves neuropathy in CMT1A and CMT1B mice

This study shows that IFB-088 treatment improves neuropathy in two mouse models of CMT1B and CMT1A by reducing ER-stress and enhancing protein homeostasis.

Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy

This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.

Enhanced axonal Neuregulin-1 type-III signaling ameliorates disease severity in a CMT1B mouse model

This study shows that enhancing Nrg1TIII signaling reduces disease severity in a CMT1B mouse model by rebalancing myelin lipids and proteins, not through myelin gene upregulation.