Ubaldo Del Carro

This study shows that deleting Sarm1 reduces axonal degeneration in a CMT2J mouse model, but does not fully prevent disease progression.

This study shows that activating XBP1s reduces disease severity in CMT1B models by mitigating ER stress and mutant protein toxicity in Schwann cells.

This study shows that IFB-088 treatment improves neuropathy in two mouse models of CMT1B and CMT1A by reducing ER-stress and enhancing protein homeostasis.

This study shows that enhancing Nrg1TIII signaling reduces disease severity in a CMT1B mouse model by rebalancing myelin lipids and proteins, not through myelin gene upregulation.