FABP8/PMP2 is a positive regulator of PNS myelination
Jiayue Hong, Clémence Roué, Simar Arora…·Sophie Belin
This study shows that increasing PMP2 in Schwann cells enhances myelin thickness without affecting ultrastructure or nerve function.
Author
Albany Medical CollegeORCID 0000-0001-5775-3298Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Jiayue Hong, Clémence Roué, Simar Arora…·Sophie Belin
This study shows that increasing PMP2 in Schwann cells enhances myelin thickness without affecting ultrastructure or nerve function.
Jenica Acheta, Amanda S. Mondschein, Marie Collison…·Yannick Poitelon
This study shows that low-intensity ultrasound increases Schwann cell proliferation and NGF expression by activating TAZ, suggesting a role in promoting neurotrophic support.
Ed Zandro M. Taroc, Enrico Amato, Alexis M. Semon…·Paolo Emanuele Forni
The paper investigates the role of Yap and Taz in OEC and Schwann cell development using single-cell RNA sequencing and conditional ablation in mice, finding differential impacts without affecting GnRH-1 migration.
Michael R. Weaver, Dominika Paula Shkoruta, Marta Pellegatta…·M. Laura Feltri
This study identifies striatin-3 as a Rac1 interactor and shows its role in Schwann cell radial sorting and Hippo pathway regulation during peripheral nervous system development.
Sophie Belin, Bruce A. Maki, James P. Catlin…·Gabriela Popescu
The paper shows membrane stretch can activate NMDA receptors without glutamate, preserving their biophysical features.
Lisa S. Robison, Olivia J. Gannon, Melissa A. Thomas…·Kristen L. Zuloaga
This study investigates how sex and high fat diet affect metabolic and hypothalamic disturbances in 3xTg-AD mice, finding sex-specific differences in metabolic outcomes and hypothalamic inflammation.
Pietro Fratta, Francesca Ornaghi, Gabriele Dati…·Lawrence G. Wrabetz
Sophie Belin, Francesca Ornaghi, Ghjuvan’Ghjacumu Shackleford…·Lawrence G. Wrabetz
This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.
Cristina Scapin, Cinzia Ferri, Emanuela Pettinato…·Maurizio D’Antonio
This study shows that enhancing Nrg1TIII signaling reduces disease severity in a CMT1B mouse model by rebalancing myelin lipids and proteins, not through myelin gene upregulation.