Structure - silencing duration relationships in RNAi medicines in rapidly dividing cells
Anastasia Kremer, Tatyana Ryaykenen, Xavier Segarra-Visent, Melanie Sauer, Leon Breuer, Yi‐Ying Wu, Qi Tang, David A. Cooper, Dimas Echeverria, Clothilde Philouze, Emilie Bayon, Dan Georgess, Réka Ágnes Haraszti
This study examines how chemical modifications affect the duration of RNAi-based therapies in rapidly dividing cells, finding that specific modifications can extend silencing duration significantly.
Molecular Therapy · Aug 12, 2025Peer-reviewedPharmacology & Toxicology