Pharmacology & ToxicologyMolecular TherapyPeer-reviewed
Structure - silencing duration relationships in RNAi medicines in rapidly dividing cells
Anastasia Kremer, Tatyana Ryaykenen, Xavier Segarra-Visent…·Réka Ágnes Haraszti
This study examines how chemical modifications affect the duration of RNAi-based therapies in rapidly dividing cells, finding that specific modifications can extend silencing duration significantly.