A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.
Kaan S. Kumru, Zi W. Yao, Brandon B. Holmes, Fangzhu Zhao, Yun Zhang, Emilio Ferrara, Trenton M. Peters-Clarke, Kevin K. Leung, James A. Wells
The paper expands the kineTAC toolbox by creating 81 new cytokine receptor-targeting chimeras for cell-type-specific extracellular protein degradation.
Proceedings of the National Academy of Sciences · Jan 21, 2026Peer-reviewedSynthetic Biology