Fangzhu Zhao

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

Directed evolution of a stem-helix targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

This paper describes the directed evolution of an antibody to enhance its binding affinity for MERS-CoV, resulting in cross-neutralization against multiple betacoronaviruses.

Targeted shedding of extracellular membrane proteins by induced protease recruitment

This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.

A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.

The paper expands the kineTAC toolbox by creating 81 new cytokine receptor-targeting chimeras for cell-type-specific extracellular protein degradation.

Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α

The paper uses chemoproteomics to identify immunogenic cell surface substrates of CK2α in the tumor microenvironment, showing that extracellular phosphorylation can generate immunogenic antigens.