Kevin Leung

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

High-resolution photocatalytic crosslinking of protein neighborhoods using contact-dependent antibody mapping (contactMAP)

The paper introduces contactMAP, a photocatalytic crosslinking method for high-resolution mapping of protein neighborhoods, showing it rivals or outperforms existing photo-PLP methods.

Targeted shedding of extracellular membrane proteins by induced protease recruitment

This paper develops Shedders, bispecific antibodies that recruit ADAM10 to induce ectodomain shedding of cell surface proteins, demonstrating efficacy in depleting LAG-3 and identifying new targets for therapeutic intervention.

A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.

The paper expands the kineTAC toolbox by creating 81 new cytokine receptor-targeting chimeras for cell-type-specific extracellular protein degradation.

β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity

This study shows that β-amyloid induces microglial GPC4 and APOE, which increases neuronal tau pathology and toxicity.

Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

Hypoxia induces extensive protein and proteolytic remodeling of the cell surface in pancreatic adenocarcinoma (PDAC) cell lines

This study identifies hypoxia-induced proteolytic remodeling of cell surface and secreted proteins in PDAC cell lines, highlighting potential biomarkers and therapeutic targets.

Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling

The paper identifies cell surface proteins upregulated in TSC1 mutant cells that offer therapeutic targets beyond mTORC1 inhibition.