The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics
Amanda Z. Velez, Jana N. Radin, Emily N. Kennedy, Joshua B. Parsons, Heather M. Tong, Emma Jung, Emily Alam, Lauren C. Radlinski, Nikki J. Wagner, Vance G. Fowler, Sarah E. Rowe, Thomas E. Kehl‐Fie, Brian P. Conlon
This study shows that calprotectin reduces β-lactam antibiotic efficacy by inactivating bacterial autolysins through zinc sequestration, independent of bacterial growth.
bioRxiv · May 14, 2025 · PreprintMicrobiology