Nikki J. Wagner

A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics

This study identifies a host-directed adjuvant, KL1, that increases intracellular bacterial energy and sensitizes persisters to antibiotics by modulating host immune responses and reducing reactive species production.

The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics

This study shows that calprotectin reduces β-lactam antibiotic efficacy by inactivating bacterial autolysins through zinc sequestration, independent of bacterial growth.