Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes
Sayed Obaidullah Aseem, Jing Wang, Maleeha F. Kalaiger, Grayson W. Way, Derrick Zhao, Yunling Tai, Emily C. Gurley, Jing Zeng, Xuan Wang, L. Ashley Cowart, Robert C. Huebert, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Arun Jayant Sanyal, Huiping Zhou
This study shows Aramchol reduces fibrosis in mouse models of biliary disease by inhibiting TGFβ-induced inflammation and fibrotic markers in cholangiocytes.
Hepatology Communications · Jul 28, 2025Peer-reviewedCell Biology