Emily C. Reed

Norepinephrine is a novel and essential regulator for T-lymphocyte interleukin 17A expression

This study identifies norepinephrine as a novel regulator of T-lymphocyte IL-17A expression through a noncanonical pathway involving TGFβ, cAMP, PKA, CREB, and CBP/p300, distinct from the canonical STAT3-dependent pathway.

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

This study identifies hemoglobin alpha's role in T-lymphocyte activation and mitochondrial function, showing its impact on cytokine production and EAE severity.

Psychological trauma increases blood pressure sensitivity to angiotensin II via T-lymphocytes independent of psychopathology

This study shows that traumatic stress increases blood pressure sensitivity to angiotensin II via T-lymphocytes, independent of psychopathology, using a mouse model of repeated social defeat stress.

Beta Adrenergic Signaling as a Therapeutic Target for Autoimmunity

This study investigates the therapeutic potential of beta-adrenergic receptor inhibition in autoimmune diseases by showing its ability to reduce TH17 cells and promote Treg cells in an experimental model of multiple sclerosis.

Hemoglobin alpha is a redox-sensitive mitochondrial-related protein in T-lymphocytes

This study identifies hemoglobin alpha-a1 as a redox-sensitive mitochondrial antioxidant in T-lymphocytes, showing its regulation by redox stress and metabolic state.

Beta-adrenergic signaling and T-lymphocyte-produced catecholamines are necessary for interleukin 17A synthesis

This study shows that beta-adrenergic signaling and T-lymphocyte-produced catecholamines are required for IL-17A synthesis, offering new therapeutic targets for PTSD and autoimmune diseases.