Coordinated IL-2 and TGF-β Signaling Activates Stable Regulatory T Cells and Promotes Immune Tolerance
Nicholas M. Jackson, Javier A. Carrero, Kristin Yeung, Evelyn Needham, Emily Christie, Natalie Yakobian, Challen A. Pretorius, Stella G. Hoft, Kirsten Foley, Eric L. Ford, Simon Low, Ronald D. Seidel III, Anish Suri, Natasha M. Girgis, Steven N. Quayle, Richard J. DiPaolo
This study shows coordinated IL-2 and TGF-β3 signaling expands and activates regulatory T cells, reduces autoimmune responses, and promotes immune tolerance.
bioRxiv · Mar 27, 2026 · PreprintImmunology