Anish Suri

The paper shows that TCR and IL2 receptor signaling synergize at the immunological synapse of CD8+ T cells, enhancing T-T synapse formation and function.

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

This study shows coordinated IL-2 and TGF-β3 signaling expands and activates regulatory T cells, reduces autoimmune responses, and promotes immune tolerance.