Author

Tanaji T. Talele

St. John's UniversityORCID 0000-0002-5938-6505Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew J. WicksiD· 1 shared Andrew N.J. TuttiD· 1 shared Ben E. BlackiD· 1 shared Christopher J. LordiD· 1 shared Daniel B. WeekesiD· 1 shared Dragomir B. KrasteviD· 1 shared Eleanor G. Knight· 1 shared Emily S. Smith-Pillet· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Andrew J. WicksORCID

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2 papers

Recent·Most cited

A PARP2-specific active site alpha-helix melts to permit DNA damage-induced enzymatic activation

Emily S. Smith-Pillet, Ramya Billur, Marie-France Langelier, Tanaji T. Talele, John M. Pascal, Ben E. Black

This study identifies structural differences in PARP1 and PARP2 activation mechanisms, showing that PARP2 requires an active site alpha-helix to be unfolded for DNA damage-induced activation, unlike PARP1.

Molecular Cell · Jan 30, 2025Peer-reviewedBiochemistry

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel B. Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Pardo, Lu Yu, Tanaji T. Talele, Jiří Bártek, Jyoti Sharma Choudhary, Yves G. Pommier, , Christopher J. Lord

The paper identifies p97 ATPase as a key player in removing trapped PARP1 from chromatin, enhancing PARPi-induced cytotoxicity in homologous recombination-defective cells.

Nature Cell Biology · Jan 1, 2022Peer-reviewedMolecular Biology