Author

Kara Heeren

VIB-KU Leuven Center for Brain & Disease Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Ludo Van Den BoschiD· 2 shared Alex Volkov· 1 shared Anna Bratek‐SkickiiD· 1 shared Anwesha BanerjeeiD· 1 shared Devesh C. PantiD· 1 shared Elke BraemsiD· 1 shared Emma Davis· 1 shared Eveline PeetersiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Ludo Van Den BoschORCID

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2 papers

Recent·Most cited

Inhibiting toxicity of ALS-linked dipeptide repeat proteins by polystyrene sulfonate (PSS)

Anna Bratek‐Skicki, Junaid Ahmed, Joris Van Lindt, Karl Jonckheere, Eveline Peeters, Kara Heeren, Fatemeh Fakhri, Alex Volkov, Jelle Hendrix, Piotr Batys, Peter Nagy, Richard G. Pestell, Ludo Van Den Bosch, Péter Tompa

This study shows that polystyrene sulfonate (PSS) reduces toxicity of ALS-linked dipeptide repeat proteins in cellular and iPSC-derived motor neuron models.

bioRxiv · May 19, 2023 · PreprintMolecular Biology

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS

Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C. Pant, Keena Yin, Seneshaw Asress, Kara Heeren, Anwesha Banerjee, Emma Davis, Samantha L. Schwartz, Graeme L. Conn, Gary Jonathan Bassell, Ludo Van Den Bosch, Jie Jiang

This study identifies that antisense C4G2 repeat expanded RNAs, but not sense G4C2, activate the PKR/eIF2-dependent integrated stress response in C9orf72 FTD/ALS, leading to neuronal toxicity.

eLife · Apr 19, 2023Peer-reviewedNeuroscience