Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer
Sarah Nersesian, John Abou‐Hamad, Emma Durocher, Gaëlle Akiki, Céline Domecq, Athena Southworth, Katrina N. Verey, Hugh H. Deng, Yudith Ramos-Valdes, Liliane Meunier, Manon de Ladurantaye, Trevor G. Shepherd, Anne-Marie Mes Masson, Anne-Marie Mes-Masson, Basile Tessier Cloutier, David P. Cook
The paper identifies a polarization axis in ovarian cancer cells linked to tumor architecture and survival, showing SecB cells correlate with poor prognosis and metastasis.
bioRxiv · Oct 22, 2026 · PreprintCancer Biology