Cyclic tri-adenylate signalling by a Panoptes anti-phage guard system with a CARF-TM effector
Sabine Grüschow, Peter J. Wotherspoon, Emma Hilton-Balfe, Shirley Graham, Malcolm F. White
The paper shows the type II Panoptes system generates cyclic tri-adenylate (cA3) to keep a CARF-TM effector inactive, and its degradation leads to membrane permeabilization and growth arrest.
bioRxiv · Mar 14, 2026 · PreprintBiochemistry