Author

Sabine Grüschow

University of St Andrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Malcolm F. WhiteiD· 3 shared Shirley GrahamiD· 2 shared Edith A. PaxtoniD· 1 shared Emma Hilton-Balfe· 1 shared Finn E. GreyiD· 1 shared Haotian ChiiD· 1 shared Keith R. MatthewsiD· 1 shared Liam J. MorrisoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

Malcolm F. WhiteORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cyclic tri-adenylate signalling by a Panoptes anti-phage guard system with a CARF-TM effector

Sabine Grüschow, Peter J. Wotherspoon, Emma Hilton-Balfe, Shirley Graham, Malcolm F. White

The paper shows the type II Panoptes system generates cyclic tri-adenylate (cA3) to keep a CARF-TM effector inactive, and its degradation leads to membrane permeabilization and growth arrest.

bioRxiv · Mar 14, 2026 · PreprintBiochemistry

Diversity and abundance of ring nucleases in type III CRISPR-Cas loci

Ville Hoikkala, Haotian Chi, Sabine Grüschow, Shirley Graham, Malcolm F. White

The paper analyzes type III CRISPR-Cas loci across 38,742 prokaryotic genomes to identify and characterize ring nucleases that regulate cyclic oligoadenylate levels.

Philosophical Transactions of the Royal Society B Biological Sciences · Sep 4, 2025Peer-reviewedBioinformatics

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomiasis

Sabine Grüschow, Pieter C. Steketee, Edith A. Paxton, Keith R. Matthews, Liam J. Morrison, Malcolm F. White, Finn E. Grey

This paper develops a Cas10-based lateral flow assay for detecting 7SL-sRNA in cattle with active trypanosomiasis, showing high sensitivity and specificity during chronic infection phases.

PLoS neglected tropical diseases · Mar 17, 2025Peer-reviewedMicrobiology