Peter J. Wotherspoon

Cyclic tri-adenylate signalling by a Panoptes anti-phage guard system with a CARF-TM effector

The paper shows the type II Panoptes system generates cyclic tri-adenylate (cA3) to keep a CARF-TM effector inactive, and its degradation leads to membrane permeabilization and growth arrest.

The SUMO activating enzyme subunit, SAE2, contributes SUMO protein bias for mitotic fidelity.

This study shows that SAE2 deacetylation during mitosis biases SUMO2 over SUMO1 conjugation, affecting mitotic fidelity through SUMOylation of NuMA.

MlaFEDB displays flippase activity to promote phospholipid transport towards the outer membrane of Gram-negative bacteria

This study identifies MlaFEDB as a flippase that uses ATP hydrolysis to transport phospholipids between membrane leaflets and shows ATP-independent phospholipid loading into MlaC.