Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP2 regeneration and activation of Kir2.1 channels.
Maria F. Noterman, María Sancho, Saúl Huerta de la Cruz, Michael T. Yarboro, Maurizio Mandalà, Masayo Koide, Nathalie Beaufort, Katalin Völgyi, Emma Moreland, David C. Hill‐Eubanks, Martin Dichgans, Mark T. Nelson
This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.
bioRxiv · Dec 25, 2025 · PreprintNeuroscience