Mark T. Nelson

Spatial uncoupling of endothelial calcium signaling from phosphatidylserine externalization in vascular injury

This study shows that endothelial calcium signaling spreads widely during vascular injury, but phosphatidylserine externalization remains localized, revealing spatial uncoupling between calcium signaling and phospholipid scrambling.

G-protein coupled receptor activity mediates detrusor smooth muscle phasic contractility through regulation of membrane potential

This study investigates how GqPCR activity regulates detrusor smooth muscle phasic contractions and transient pressure events through effects on Ca2+ activity and membrane potential.

Electromechanical Dynamics and Myogenic Responses in Cerebral Smooth Muscle Cells and Capillary Pericytes

This study develops a mathematical model of cerebral mural cell electrophysiology and biomechanics to understand myogenic responses in arterioles and capillaries, revealing how Ca2+ dynamics and ion channel activity influence vascular resistance.

Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease

This study shows that electro-calcium uncoupling in endothelial cells precedes neurodegeneration and cognitive decline in 5xFAD mice.

Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP2 regeneration and activation of Kir2.1 channels.

This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels

This study shows adenosine and low oxygen reduce bladder contractility via A2B receptors and BKCa channels in mice.

Charge Screening by Extracellular Ca2+ Shields Endothelial Cells from Histone Injury and Permits Membrane Repair

The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.

Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature

This study shows that pathogenic tau peptides reduce endothelial calcium signaling and vasodilation in brain microvessels, impairing cerebral blood flow.

Electro-Metabolic Sensing Through Capillary ATP-Sensitive K+ Channels and Adenosine to Control Cerebral Blood Flow

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.

Vascular control of the CO2/H+ dependent drive to breathe

The paper identifies P2Y2 receptors in RTN vascular smooth muscle cells as essential for CO2/H+ chemoreception and respiratory behavior in mice.