María Sancho

This study develops a mathematical model of cerebral mural cell electrophysiology and biomechanics to understand myogenic responses in arterioles and capillaries, revealing how Ca2+ dynamics and ion channel activity influence vascular resistance.

This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.

This study shows adenosine and low oxygen reduce bladder contractility via A2B receptors and BKCa channels in mice.

This study investigates the role of CaV3.1 T-type Ca2+ channels in myogenic tone and calcium wave generation in mouse mesenteric arteries, finding reduced tone and calcium waves in their absence.

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.

The paper shows that intercellular electrical signaling through gap junctions coordinates vascular responses to maintain blood flow during cerebrovascular challenges.

The paper investigates how membrane lipids modulate KIR channels in cerebral arteries to sense hemodynamic stimuli and regulate brain perfusion.