Saúl Huerta de la Cruz

Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP2 regeneration and activation of Kir2.1 channels.

This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels

This study shows adenosine and low oxygen reduce bladder contractility via A2B receptors and BKCa channels in mice.

Electro-Metabolic Sensing Through Capillary ATP-Sensitive K+ Channels and Adenosine to Control Cerebral Blood Flow

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.