INPP5D/SHIP1 regulates endo-lysosome function and cargo-selective phagocytosis in human microglia
Gizem Terzioğlu, Emma S. Karp, Sarah E. Heuer, Jean Paul Chadarevian, Fasih M. Ahsan, Verena Claudia Haage, Hayk Davtyan, Garrett M. Fogo, Annabel J. Curle, Nancy Ashour, Courtney R. Benoit, Jillian Schmottlach, Anna E. Cramer, Christina R. Muratore, Duc M. Duong, , Tracy L. Young‐Pearse
This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.
bioRxiv · Oct 27, 2025 · PreprintNeuroscience